22.6 The Elongation and Unsaturation of Fatty Acids Are Accomplished by Accessory Enzyme Systems

Membrane-bound Enzymes (Complex):

 
 

NADH-cytochrome reductase,

cytochrome b5,

desaturase

 
 

*This oxidase complex catalyses formation of oleoyl coA from stearoyl coA (see p.634 Fig 22.32)

 
 

Eucosanoid hormones:

 
 

• Prostaglandins,
  
• prostacyclins,
  
• thromboxanes,
  
• and leukotrienes
  

   
   

  They are synthesized from Arachidonate
  

   
   

  Eucosanoids are local hormones that stimulate inflammation, regulate blood flow to particular organs, control ion transport across membranes, modulate synaptic transmission, and induce sleep.
  

   
   

  Aspirin block active site of prostaglandin synthase.